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1

Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach

Krackhardt, Angela M., Anliker, Brigitte, Hildebrandt, Martin, Bachmann, Michael, Eichmüller, Stefan B., Nettelbeck, Dirk M., Renner, Matthias, Uharek, Lutz, Willimsky, Gerald, Schmitt, Michael, Wels,

Journal:

Cancer Immunology, Immunotherapy

Year:

2018

Language:

english

File:

PDF, 944 KB

english, 2018

2

Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses

Stephan Schierer, Andrea Hesse, Ina Müller, Eckhart Kämpgen, David T. Curiel, Gerold Schuler, Alexander Steinkasserer, Dirk M. Nettelbeck

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 3.23 MB

english, 2008

3

Cellular genetic tools to control oncolytic adenoviruses for virotherapy of cancer

Dirk M. Nettelbeck

Journal:

Journal of Molecular Medicine

Year:

2008

Language:

english

File:

PDF, 613 KB

english, 2008

4

Virotherapeutics: conditionally replicative adenoviruses for viral oncolysis

Nettelbeck, Dirk M.

Journal:

Anti-Cancer Drugs

Year:

2003

Language:

english

File:

PDF, 280 KB

english, 2003

5

Cell cycle-independent induction of apoptosis by the anti-tumor drug flavopiridol in endothelial cells

Sabine Brüsselbach, Dirk M. Nettelbeck, Hans-Harald Sedlacek, Rolf Müller

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 173 KB

english, 1998

6

Retargeting of adenoviral infection to melanoma: Combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAA

Dirk M. Nettelbeck, Angel A. Rivera, Jörg Kupsch, Detlef Dieckmann, Joanne T. Douglas, Roland E. Kontermann, Ramon Alemany, David T. Curiel

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 1.97 MB

english, 2004

7

Combining adenoviral oncolysis with temozolomide improves cell killing of melanoma cells

Christina Quirin, Astrid Mainka, Andrea Hesse, Dirk M. Nettelbeck

Journal:

International Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 312 KB

english, 2007

8

Human dendritic cells efficiently phagocytose adenoviral oncolysate but require additional stimulation to mature

Stephan Schierer, Andrea Hesse, Ilka Knippertz, Eckhart Kaempgen, Andreas S. Baur, Gerold Schuler, Alexander Steinkasserer, Dirk M. Nettelbeck

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 2.13 MB

english, 2012

9

Insulated hsp70B′ promoter: stringent heat-inducible activity in replication-deficient, but not replication-competent adenoviruses

Stanimira Rohmer, Astrid Mainka, Ilka Knippertz, Andrea Hesse, Dirk M. Nettelbeck

Journal:

The Journal of Gene Medicine

Year:

2008

Language:

english

File:

PDF, 1.49 MB

english, 2008

10

Recombinant bispecific antibodies for the targeting of adenoviruses to CEA-expressing tumour cells: a comparative analysis of bacterially expressed single-chain diabody and tandem scFv

Tina Korn, Dirk M. Nettelbeck, Tina Völkel, Rolf Müller, Roland E. Kontermann

Journal:

The Journal of Gene Medicine

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

11

Evaluation of tissue-specific promoters in carcinomas of the cervix uteri

Daniel T. Rein, Martina Breidenbach, Dirk M. Nettelbeck, Yosuke Kawakami, Gene P. Siegal, Warner K. Huh, Minghui Wang, Akseli Hemminki, Gerd J. Bauerschmitz, Masato Yamamoto, Yasuo Adachi, Koichi Taka

Journal:

The Journal of Gene Medicine

Year:

2004

Language:

english

File:

PDF, 133 KB

english, 2004

12

Tumor-Busting Viruses

Nettelbeck, Dirk M., Curiel, David T.

Journal:

Scientific American

Year:

2003

Language:

english

File:

PDF, 494 KB

english, 2003

13

Transcriptional targeting of tumors with a novel tumor-specific survivin promoter

Zhu, Zeng B, Makhija, Sharmila K, Lu, Baogen, Wang, Minghui, Kaliberova, Lioudmila, Liu, Bin, Rivera, Angel A, Nettelbeck, Dirk M, Mahasreshti, Parameshwar J, Leath, Charles A

Journal:

Cancer Gene Therapy

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

14

Employment of microarray analysis to characterize biologic differences associated with tropism-modified adenoviral vectors: utilization of non-native cellular entry pathways

Volk, Andrea L, Rivera, Angel A, Page, Grier P, Salazar-Gonzalez, Jesus F, Nettelbeck, Dirk M, Matthews, Qiana L, Curiel, David T

Journal:

Cancer Gene Therapy

Year:

2004

Language:

english

File:

PDF, 429 KB

english, 2004

15

Evaluation of Twenty-One Human Adenovirus Types and One Infectivity-Enhanced Adenovirus for the Treatment of Malignant Melanoma

Hoffmann, Dennis, Bayer, Wibke, Heim, Albert, Potthoff, Anja, Nettelbeck, Dirk M, Wildner, Oliver

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 1.13 MB

english, 2007

16

Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

Dominik E. Dorer, Dirk M. Nettelbeck

Journal:

Advanced Drug Delivery Reviews

Year:

2009

Language:

english

File:

PDF, 1.05 MB

english, 2009

17

Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo

Angel A. Rivera, Minghui Wang, Kaori Suzuki, Taco G. Uil, Victor Krasnykh, David T. Curiel, Dirk M. Nettelbeck

Journal:

Year:

2004

Language:

english

File:

PDF, 883 KB

english, 2004

18

Transgene expression by oncolytic adenoviruses is modulated by E1B19K deletion in a cell type-dependent manner

Stanimira Rohmer, Christina Quirin, Andrea Hesse, Stefanie Sandmann, Wibke Bayer, Christel Herold-Mende, Yosef S. Haviv, Oliver Wildner, Alexander H. Enk, Dirk M. Nettelbeck

Journal:

Year:

2009

Language:

english

File:

PDF, 1.93 MB

english, 2009

19

Gene therapy: designer promoters for tumour targeting

Dirk M Nettelbeck, Valérie Jérôme, Rolf Müller

Journal:

Trends in Genetics

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

20

A novel dynamic matrix detachment model reveals a shift from apoptosis to necrosis in melanoma cells

Keren Tzukert, Raphael Gorodestky, Idit Avrahami, Lina Krasny, Nilly Shimony, Gregory Elkin, Dirk M. Nettelbeck, Yosef S. Haviv

Journal:

Year:

2008

Language:

english

File:

PDF, 507 KB

english, 2008

21

Virus chimeras for gene therapy, vaccination, and oncolysis: adenoviruses and beyond

Johanna K. Kaufmann, Dirk M. Nettelbeck

Journal:

Trends in Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 5.59 MB

english, 2012

22

Cell type specificity of the human endoglin promoter

Wolff Graulich, Dirk M Nettelbeck, Dagmar Fischer, Thomas Kissel, Rolf Müller

Journal:

Year:

1999

Language:

english

File:

PDF, 351 KB

english, 1999

23

Chemovirotherapy of Malignant Melanoma with a Targeted and Armed Oncolytic Measles Virus

Kaufmann, Johanna K, Bossow, Sascha, Grossardt, Christian, Sawall, Stefanie, Kupsch, Jörg, Erbs, Philippe, Hassel, Jessica C, von Kalle, Christof, Enk, Alexander H, Nettelbeck, Dirk M, Ungerechts, Guy

Journal:

The Journal of Investigative Dermatology

Year:

2013

Language:

english

File:

PDF, 2.68 MB

english, 2013

24

Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies

Knippertz, Ilka, Stein, Marcello F., Dörrie, Jan, Schaft, Niels, Müller, Ina, Deinzer, Andrea, Steinkasserer, Alexander, Nettelbeck, Dirk M.

Journal:

International Journal of Hyperthermia

Year:

2011

Language:

english

File:

PDF, 766 KB

english, 2011

25

Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

Ketzer, Patrick, Kaufmann, Johanna K., Engelhardt, Sarah, Bossow, Sascha, von Kalle, Christof, Hartig, Jörg S., Ungerechts, Guy, Nettelbeck, Dirk M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.35 MB

english, 2014

26

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

Engeland, Christine E, Grossardt, Christian, Veinalde, Rūta, Bossow, Sascha, Lutz, Diana, Kaufmann, Johanna K, Shevchenko, Ivan, Umansky, Viktor, Nettelbeck, Dirk M, Weichert, Wilko, Jäger, Dirk, von

Journal:

Molecular Therapy

Year:

2014

Language:

english

File:

PDF, 2.19 MB

english, 2014

27

Genetic Replacement of the Adenovirus Shaft Fiber Reduces Liver Tropism in Ovarian Cancer Gene Therapy

Breidenbach, Martina, Rein, Daniel T., Wang, Minghui, Nettelbeck, Dirk M., Hemminki, Akseli, Ulasov, Ilya, Rivera, Angel A., Everts, Maaike, Alvarez, Ronald D., Douglas, Joanne T., Curiel, David T.

Journal:

Human Gene Therapy

Year:

2004

Language:

english

File:

PDF, 175 KB

english, 2004

28

Evaluation of Twenty Human Adenoviral Types and One Infectivity-Enhanced Adenovirus for the Therapy of Soft Tissue Sarcoma

Hoffmann, Dennis, Heim, Albert, Nettelbeck, Dirk M., Steinstraesser, Lars, Wildner, Oliver

Journal:

Human Gene Therapy

Year:

2007

Language:

english

File:

PDF, 1.10 MB

english, 2007

29

Selectivity and Efficiency of Late Transgene Expression by Transcriptionally Targeted Oncolytic Adenoviruses Are Dependent on the Transgene Insertion Strategy

Quirin, Christina, Rohmer, Stanimira, Fernández-Ulibarri, Inés, Behr, Michael, Hesse, Andrea, Engelhardt, Sarah, Erbs, Philippe, Enk, Alexander H., Nettelbeck, Dirk M.

Journal:

Human Gene Therapy

Year:

2011

Language:

english

File:

PDF, 943 KB

english, 2011

30

Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cells

Hammer, Katharina, Kazcorowski, Adam, Liu, Li, Behr, Michael, Schemmer, Peter, Herr, Ingrid, Nettelbeck, Dirk M.

Journal:

International Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

31

Tumor-Busting Viruses

Nettelbeck, Dirk M., Alvarez, Ronald D., Curiel, David T.

Journal:

Scientific American Sp

Year:

2008

Language:

english

File:

PDF, 757 KB

english, 2008

32

An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma

Takikawa, Hiroto, Mafune, Ken-Ichi, Hamada, Hirofumi, Nettelbeck, Dirk, Müller, Rolf, Makuuchi, Masatoshi, Kaminishi, Michio

Journal:

International Journal of Oncology

Year:

2003

Language:

english

File:

PDF, 1.50 MB

english, 2003

33

Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism

Volk, Andrea L., Rivera, Angel A., Kanerva, Anna, Bauerschmitz, Gerd, Dmitriev, Igor, Nettelbeck, Dirk M., Curiel, David T.

Journal:

Cancer Biology & Therapy

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

34

A single chain immunotoxin, targeting the melanoma-associated chondroitin sulfate proteoglycan, is a potent inducer of apoptosis in cultured human melanoma cells

Schwenkert, Michael, Birkholz, Katrin, Schwemmlein, Michael, Kellner, Christian, Kügler, Markus, Peipp, Matthias, Nettelbeck, Dirk M., Schuler-Thurner, Beatrice, Schaft, Niels, Dörrie, Jan, Ferrone, S

Journal:

Melanoma Research

Year:

2008

Language:

english

File:

PDF, 308 KB

english, 2008

35

Generation of Human Dendritic Cells That Simultaneously Secrete IL-12 and Have Migratory Capacity by Adenoviral Gene Transfer of hCD40L in Combination With IFN-γ

Knippertz, Ilka, Hesse, Andrea, Schunder, Tanja, Kämpgen, Eckhart, Brenner, Malcolm K., Schuler, Gerold, Steinkasserer, Alexander, Nettelbeck, Dirk M.

Journal:

Journal of Immunotherapy

Year:

2009

Language:

english

File:

PDF, 497 KB

english, 2009

36

Conference Report: 17th Annual Meeting of the German Society for Gene Therapy

Büning, Hildegard, Baum, Christopher, Ehrhardt, Anja, Nettelbeck, Dirk M, Ogris, Manfred

Journal:

Therapeutic Delivery

Year:

2011

Language:

english

File:

PDF, 421 KB

english, 2011

37

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: Results in vitro , in rodents and in humans

Bramante, Simona, Kaufmann, Johanna K., Veckman, Ville, Liikanen, Ilkka, Nettelbeck, Dirk M., Hemminki, Otto, Vassilev, Lotta, Cerullo, Vincenzo, Oksanen, Minna, Heiskanen, Raita, Joensuu, Timo, Kaner

Journal:

International Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 446 KB

english, 2015

38

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

Ungerechts, Guy, Bossow, Sascha, Leuchs, Barbara, Holm, Per S, Rommelaere, Jean, Coffey, Matt, Coffin, Rob, Bell, John, Nettelbeck, Dirk M

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

39

194. Adenoviruses Armed with TNFα and IL-2 Successfully Enable Adoptive T-Cell Therapy

Kalervo, Aino, Siurala, Mikko, Havunen, Riikka, Parviainen, Suvi, Bramante, Simona, Saha, Dipongor, Tähtinen, Siri, Vähä-Koskela, Markus, Behr, Michael, Nettelbeck, Dirk, Ehrhardt, Anja, Hemminki, Aks

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 569 KB

english, 2016

40

410. Oncolytic Adenoviruses Armed with TNFa and IL-2 Induce Antitumor Immune Responses and Protection from Tumor Rechallenge

Havunen, Riikka, Siurala, Mikko, Parviainen, Suvi, Behr, Michael, Nettelbeck, Dirk, Ehrhardt, Anja, Hemminki, Akseli

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 298 KB

english, 2016

41

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

Havunen, Riikka, Siurala, Mikko, Sorsa, Suvi, Grönberg-Vähä-Koskela, Susanna, Behr, Michael, Tähtinen, Siri, Santos, João Manuel, Karell, Pauliina, Rusanen, Juuso, Nettelbeck, Dirk M., Ehrhardt, Anja,

Journal:

Molecular Therapy — Oncolytics

Year:

2017

Language:

english

File:

PDF, 1.61 MB

english, 2017

42

An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy

Douglas, Joanne, Lesniak, Maciej, Wang, Ming, Tyler, Matthew, Sonabend, Adam, Mathis, J., Rivera, Lisa, Nettelbeck, Dirk, Ulasov, Ilya, Rivera, Angel

Journal:

International Journal of Oncology

Year:

2007

Language:

english

File:

PDF, 318 KB

english, 2007

43

RNAi suppressor P19 can be broadly exploited for enhanced adenovirus replication and microRNA knockdown experiments

Rauschhuber, Christina, Mueck-Haeusl, Martin, Zhang, Wenli, Nettelbeck, Dirk M., Ehrhardt, Anja

Journal:

Scientific Reports

Year:

2013

Language:

english

File:

PDF, 822 KB

english, 2013

44

Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation

Knippertz, Ilka, Deinzer, Andrea, Dörrie, Jan, Schaft, Niels, Nettelbeck, Dirk M., Steinkasserer, Alexander

Journal:

Journal of Immunology Research

Year:

2016

Language:

english

File:

PDF, 2.21 MB

english, 2016

45

German Cancer Consortium (DKTK) - A national consortium for translational cancer research

Joos, Stefan, Nettelbeck, Dirk M., Reil-Held, Anette, Engelmann, Katja, Moosmann, Alexandra, Eggert, Angelika, Hiddemann, Wolfgang, Krause, Mechthild, Peters, Christoph, Schuler, Martin, Schulze-Ostho

Journal:

Molecular Oncology

Year:

2018

Language:

english

File:

PDF, 312 KB

english, 2018